TFB2M

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.^[1]

This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.^[2]

References

1. ^ "Entrez Gene: TFB2M transcription factor B2, mitochondrial"
2. ^ Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation.". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603

Further reading

• Falkenberg M, Gaspari M, Rantanen A, etal (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet.. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295. S2CID 11164308
• Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
• Rantanen A, Gaspari M, Falkenberg M, etal (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.". Mamm. Genome. 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263. S2CID 25379746
• McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol.. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151
• Ota T, Suzuki Y, Nishikawa T, etal (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039
• Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334
• Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.". EMBO J.. 23 (23): 4606–14. doi:10.1038/sj.emboj.7600465. PMC 533051. PMID 15526033
• Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.". Mol. Cell. Biol.. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387
• Gregory SG, Barlow KF, McLay KE, etal (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414
• Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.". J. Mol. Evol.. 63 (5): 707–17. doi:10.1007/s00239-006-0075-1. PMID 17031457. S2CID 7673903
• Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.". Nucleic Acids Res.. 35 (12): 4042–54. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812