| Width | 225px |
|---|---|
| Cas number | 78686-02-9 |
| Pubchem | 5706 |
| Chemspiderid | 5504 |
| Unii | 923NT4H8G3 |
| Chembl | 1616379 |
| Synonyms | N-2-Chloroethyl-N-ethyl-2-methylbenzylamine |
| Iupac name | 2-chloro-N-ethyl-N-[(2-methylphenyl)methyl]ethanamine |
| C | 12 |
| H | 18 |
| Cl | 1 |
| N | 1 |
| Smiles | CCN(CCCl)CC1=CC=CC=C1C |
| Stdinchi | 1S/C12H18ClN/c1-3-14(9-8-13)10-12-7-5-4-6-11(12)2/h4-7H,3,8-10H2,1-2H3 |
| Stdinchikey | XHRCFGDFESIFRG-UHFFFAOYSA-N |
Xylamine is a monoaminergic neurotoxin and benzylamine derivative that is closely related to DSP-4.[1][2] It is a relatively selective noradrenergic neurotoxin, which is attributed to its high affinity for the norepinephrine transporter (NET).[1] DSP-4 is generally preferred over xylamine for use in scientific research and hence xylamine is limitedly employed.[1] Xylamine was first described in 1975.[2][3]
References
- ^ Kostrzewa RM (2022). "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons". Handbook of Neurotoxicity. Cham: Springer International Publishing. pp. 159–198. doi:10.1007/978-3-031-15080-7_53. ISBN 978-3-031-15079-1.
- ^ Dudley MW, Howard BD, Cho AK (1990). "The interaction of the beta-haloethyl benzylamines, xylamine, and DSP-4 with catecholaminergic neurons". Annu Rev Pharmacol Toxicol. 30: 387–403. doi:10.1146/annurev.pa.30.040190.002131. PMID 2188573
- ^ Krueger CA, Cook DA (November 1975). "Synthesis and adrenergic neuron blocking properties of some alkylating analogues of bretylium". Arch Int Pharmacodyn Ther. 218 (1): 96–105. PMID 1212016