Exportin-T is a protein that in humans is encoded by the XPOT gene.[1][2][3]
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[3]
References
- ^ Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi:10.1016/S1097-2765(00)80036-2. PMID 9660920
- ^ Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi:10.1016/S0960-9822(98)70130-7. PMID 9512417. S2CID 17803674
- ^ "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)"
Further reading
- Arts GJ, Kuersten S, Romby P, etal (1999). "The role of exportin-t in selective nuclear export of mature tRNAs.". EMBO J.. 17 (24): 7430–41. doi:10.1093/emboj/17.24.7430. PMC 1171087. PMID 9857198
- Kruse C, Willkomm DK, Grünweller A, etal (2000). "Export and transport of tRNA are coupled to a multi-protein complex.". Biochem. J.. 346 (1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829. PMID 10657246
- Kutay U, Hartmann E, Treichel N, etal (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.". J. Biol. Chem.. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. hdl:11858/00-001M-0000-0015-3D4E-B. PMID 11024021
- Kuersten S, Arts GJ, Walther TC, etal (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains.". Mol. Cell. Biol.. 22 (16): 5708–20. doi:10.1128/MCB.22.16.5708-5720.2002. PMC 133969. PMID 12138183
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334
- Suzuki T, Koyama Y, Hayakawa S, etal (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.". Biomed. Res.. 27 (2): 89–92. doi:10.2220/biomedres.27.89. PMID 16707848
- Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA.". RNA Biol. 3 (4): 145–9. doi:10.4161/rna.3.4.3679. PMID 17224653