Triaziquone
Verifiedfieldschanged
Watchedfieldschanged
Verifiedrevid448209127
Iupac name2,3,5-tris(aziridin-1-yl)benzo-1,4-quinone
Cas number68-76-8
Atc prefixL01
Atc suffixAC02
Pubchem6235
UniiF3D5D9P25I
Chebi27090
KeggC19542
Chemspiderid5999
C12
H13
N3
O2
Synonyms
  • 2,3,5-Tris(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione
  • Tris(aziridinyl)-p-benzoquinone
SmilesC1CN1C2=CC(=O)C(=C(C2=O)N3CC3)N4CC4
Stdinchi1S/C12H13N3O2/c16-9-7-8(13-1-2-13)12(17)11(15-5-6-15)10(9)14-3-4-14/h7H,1-6H2
StdinchikeyPXSOHRWMIRDKMP-UHFFFAOYSA-N

Triaziquone is a drug used in chemotherapy.

It is aziridinylbenzoquinone-based, and may have potential antineoplastic activity. [1]

It is an alkylating agent. It can react with DNA to form intrastrand crosslinks. It is a member of aziridines as well. [2]

References

  1. ^ PubChem. "Triaziquone". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-10-10.
  2. ^ Huang CH, Kuo HS, Liu JW, Lin YL (June 2009). "Synthesis and antitumor evaluation of novel bis-triaziquone derivatives". Molecules (Basel, Switzerland). 14 (7): 2306–16. doi:10.3390/molecules14072306. PMC 6255275. PMID 19633605