Takemoto (written: , , or ) is a Japanese surname. Notable people with the surname include:
- Eiji Takemoto (竹本 英史, born 1973), Japanese voice actor
- Takemoto Gidayū (竹本 義太夫, 1651–1714), Japanese playwright and puppet theatre director
- Iwao Takamoto (1925–2007), American animator, television producer, and film director
- Izumi Takemoto (竹本 泉, born 1959), Japanese manga artist
- Kazuhiko Takemoto (竹本 一彦, born 1955), Japanese footballer and manager
- Masao Takemoto (竹本 正男, 1919–2007), Japanese artistic gymnast
- Naokazu Takemoto (竹本 直一, born 1940), Japanese politician
- Novala Takemoto (嶽本 野ばら, born 1968), Japanese author and fashion designer
- Tina Takemoto, American artist
- Yasuhiro Takemoto (武本 康弘, 1972–2019), Japanese director of anime series
- Yoshiyuki Takemoto (竹元 義幸, born 1973), Japanese footballer
- Yukari Takemoto (竹本 ゆかり, born 1955), Japanese swimmer