| Iupac name | (5α)-17-Methyl-4,5-epoxymorphinan-3,6,14-triol |
|---|---|
| Metabolism | hepatic |
| Cas number | 54934-75-7 |
| Atc prefix | N02 |
| Atc suffix | A |
| Pubchem | 6712731 |
| Chemspiderid | 5144767 |
| Unii | 67P6D5Q6YK |
| Chembl | 1968360 |
| C | 17 |
| H | 21 |
| N | 1 |
| O | 4 |
| Smiles | CN1CC[C@]23c4c5ccc(c4O[C@H]2C(CC[C@]3([C@H]1C5)O)O)O |
| Stdinchi | 1S/C17H21NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,11-12,15,19-21H,4-8H2,1H3/t11?,12-,15+,16+,17-/m1/s1 |
| Stdinchikey | AABLHGPVOULICI-ZOFKVTQNSA-N |
| Synonyms | 4,5α-Epoxy-17-methylmorphinan-3,6,14-triol |
Oxymorphol is oxymorphone which has been hydrogenated at the 6-position and consists of a mixture of 4,5α-epoxy-17-methylmorphinan-3,6β,14-triol and 4,5α-epoxy-17-methylmorphinan-3,6α,14-triol (hydromorphinol).[1] It is produced by the human body as an active metabolite of oxymorphone and some bacteria as an intermediate in turning morphine into hydromorphone.[2] It can also be manufactured and is the subject of patents by drug companies looking for new semi-synthetic analgesics and cough suppressants.
A derivative of oxymorphol, 8-hydroxy-6-α-oxymorphol, was discovered in the first decade of the 21st century and the subject of a patent application by Endo Pharmaceuticals for an analgesic and antitussive.[3]
References
- ^ "α-Oxymorphol as "Hydromorphinol""
- ^ Cone EJ, Darwin WD, Buchwald WF, Gorodetzky CW (1983). "Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 11 (5): 446–50. doi:10.1016/S0090-9556(25)08048-1. PMID 6194952
- ^ "OPIOID AND METHODS OF MAKING AND USING THE SAME - Patent application". www.faqs.org. Archived from the original on 2014-05-02.