Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.[1][2]
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.[2]
References
- ^ Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC (May 2001). "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains". J Biol Chem. 276 (4): 2802–7. doi:10.1074/jbc.M008955200. PMID 11060313
- ^ "Entrez Gene: MOAP1 modulator of apoptosis 1"
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res.. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863
- Simpson JC, Wellenreuther R, Poustka A, etal (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep.. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614
- Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
- Ota T, Suzuki Y, Nishikawa T, etal (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039
- Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334
- Wiemann S, Arlt D, Huber W, etal (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res.. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336
- Baksh S, Tommasi S, Fenton S, etal (2005). "The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.". Mol. Cell. 18 (6): 637–50. doi:10.1016/j.molcel.2005.05.010. PMID 15949439
- Rual JF, Venkatesan K, Hao T, etal (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026
- Vos MD, Dallol A, Eckfeld K, etal (2006). "The RASSF1A tumor suppressor activates Bax via MOAP-1.". J. Biol. Chem.. 281 (8): 4557–63. doi:10.1074/jbc.M512128200. PMID 16344548
- Mehrle A, Rosenfelder H, Schupp I, etal (2006). "The LIFEdb database in 2006.". Nucleic Acids Res.. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901
- Lim J, Hao T, Shaw C, etal (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569
- Fu NY, Sukumaran SK, Yu VC (2007). "Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria.". Proc. Natl. Acad. Sci. U.S.A.. 104 (24): 10051–6. Bibcode:2007PNAS..10410051F. doi:10.1073/pnas.0700007104. PMC 1877986. PMID 17535899