| Airline | Country | B1 | B2 | B4 | 600 | Still in operation | Notes[citation needed] |
|---|
| Aerocóndor Colombia | | | | 1 | | | First South American operator |
| Aerostan | | | | 2 | | | |
| AeroUnion | | | | 7 | 3 | | |
| Afriqiyah Airways | | | | | 2 | | |
| Air Afrique | | | | 4 | 4 | | Ceased operations in 2002 |
| Air Algérie | | 1 | | 2 | | | A300B1 leased from Trans European Airways A300B4 leased from Lufthansa |
| Air Atlanta Icelandic | | | | | 9 | | |
| Air France | | | 11 | 14 | | | Launch customer of the A300 |
| Air Hong Kong | | | | 1 | 13 | | |
| Air India | | | | 5 | | | |
| Air Inter | | | 16 | 6 | | | Merged into Air France in 1997 |
| Air Jamaica | | | | 8 | | | |
| Air Maldives | | | | 2 | | | |
| Air Stork | | | | 1 | | | |
| Alitalia | | | 2 | 12 | | | |
| AMS Airlines | | | | 5 | | | |
| American Airlines | | | | | 35 | | |
| Apollo Airlines | | | | 3 | | | Ceased operations in 1996 |
| ASL Airlines Ireland | | | | 17 | 8 | | |
| CEIBA Intercontinental | | | | 1 | | | Operated by MNG Airlines |
| China Airlines | | | | 6 | 14 | | |
| China Eastern Airlines | | | | | 13 | | |
| China Northern Airlines | | | | | 8 | | Merged into China Southern Airlines in 2004 |
| CityBird | | | | | 2 | | Ceased operations in 2001 |
| Continental Airlines | | | | 23 | | | |
| Conair of Scandinavia | | | | 3 | | | Merged with Scanair to form Premiair in 1994 |
| Cruzeiro do Sul | | | | 2 | | | |
| Eastern Air Lines | | | 2 | 32 | | | Ceased operations in 1991 First U.S. operator |
| Easy Charter | | | | 1 | 1 | | |
| Egyptair | | | | 10 | 12 | | |
| Egyptair Cargo | | | | 2 | 2 | | |
| Emirates | | | | 1 | 6 | | A300B4 leased from Pakistan International Airlines |
| Etihad Airways | | | | | 3 | | Leased from Air Atlanta Icelandic |
| European Air Transport | | | | 19 | 1 | | Merged into European Air Transport Leipzig in 2010 |
| European Air Transport Leipzig | | | | | 24 | | |
| FedEx Express | | | | | 71 | | Largest A300 operator |
| Finnair | | | | 2 | | | |
| Galaxy Airlines | | | | | 2 | | Ceased operations in 2008 |
| Garuda Indonesia | | | | 9 | 13 | | |
| Georgian Star International | | | | 3 | | | Ceased operations in 2015 |
| Geo Fly Airways | | | | 1 | | | |
| Global Air Transport | | | | 1 | | | Leased from Air Stork |
| Global Jet UAE | | | | | 2 | | |
| GrandAir | | | | 5 | | | |
| Hapag-Lloyd Flug | | | | 9 | 1 | | A300-600 leased from Lufthansa |
| Iberia | | | | 9 | | | |
| Indian Airlines | | | 10 | 4 | | | |
| Iran Air | | | 8 | 6 | 4 | | |
| Iran Airtour | | | | 2 | 5 | | |
| Iraqi Airways | | | | | 1 | | |
| Japan Air System | | | 9 | 8 | 22 | | Merged with Japan Airlines in 2006 |
| Korean Air | | | | 10 | 30 | | |
| Kuwait Airways | | | | 2 | 8 | | |
| Laker Airways | | | | 3 | | | Ceased operations in 1982 |
| LaTur | | | | | 2 | | Ceased operations in 1991 |
| Lufthansa | | | 6 | 5 | 15 | | |
| Mahan Air | | | 3 | 5 | 15 | | |
| Malaysia Airlines | | | | 6 | 1 | | A300-600 leased from Air Atlanta Icelandic |
| Maximus Air | | | | | 5 | | |
| Meraj Airlines | | | | | 2 | | |
| Merpati Nusantara Airlines | | | | | 1 | | Leased from Kuwait Airways |
| Middle East Airlines | | | | 1 | 1 | | |
| Midex Airlines | | | | 6 | | | |
| MNG Airlines | | | | 13 | 8 | | |
| Moalem Aviation | | | | 3 | | | |
| Monarch Airlines | | | | | 4 | | |
| MyCargo Airlines | | | | | 1 | | Operated by ACT Airlines |
| Olympic Airlines | | | | | 6 | | |
| Onur Air | | | 2 | 4 | 8 | | |
| Pakistan International Airlines | | | | 13 | | | |
| Pan Am | | | | 13 | | | Ceased operations in 1991 |
| Pan Am (1996-1998) | | | | 8 | | | Merged with Carnival Air Lines in 1998 |
| Philippine Airlines | | | | 13 | | | |
| Qantas | | | | 4 | | | acquired with Australian Airlines in 1993[2] |
| Qatar Airways | | | | | 16 | | |
| Qeshm Air | | | | 1 | 5 | | A300B4 leased from Onur Air |
| Saudi Arabian Airlines | | | 2 | 13 | 22 | | Several aircraft leased from various airlines |
| Scanair | | | | 3 | | | Sold to Conair of Scandinavia |
| Scandinavian Airlines | | | 3 | 1 | | | |
| Sempati Air | | | | 4 | | | |
| Sigma Airlines | | | | 1 | | | |
| Silk Road Cargo Business | | | | | 1 | | |
| Singapore Airlines | | | | 8 | | | |
| Solinair | | | | 1 | 2 | | |
| South African Airways | | | 4 | 5 | | | |
| Sudan Airways | | | | 5 | 6 | | |
| TACA International Airlines | | | | 5 | | | Operated by JHM Airlines Cargo |
| TAESA Lineas Aéreas | | | | 2 | | | |
| Thai Airways International | | | | 14 | 21 | | |
| The Cargo Airlines | | | | 3 | | | |
| TMA Cargo | | | | 1 | | | Ceased operations in 2014 |
| TNT Airways | | | | 4 | | | |
| Tradewinds Airlines | | | | 11 | | | Rebranded as Sky Lease Cargo in 2009 |
| Trans Australia Airlines | | | | 6 | | | Merged into Qantas in 1993 |
| Trans European Airways | | 1 | | 1 | | | Sole commercial operator of the A300B1 |
| Transcarga International Airways | | | | 4 | | | |
| Tristar Air | | | | 1 | | | |
| Tunisair | | | | 3 | 4 | | |
| Unique Air | | | | | 2 | | |
| Uni-Top Airlines | | | | | 7 | | Ceased operations in 2019 |
| UPS Airlines | | | | | 53 | | |
| Uzbekistan Airways | | | | | 2 | | Leased from Korean Air |
| Varig | | | | 2 | | | |
| VASP | | | 3 | | | | Ceased operations in 2005 |
| Viasa | | | | 4 | | | |
| Vietnam Airlines | | | | 2 | 1 | | |