| State | Minnesota |
|---|---|
| Term start | March 4, 1843 |
| Term end | March 3, 1847 |
| Preceded | New seat |
| Succeeded | District dissolved |
| State house 2 | Minnesota |
| Term start 2 | 1835 |
| Term end 2 | 1844 |
| Birth name | James Hugh Relfe |
| Birth date | October 17, 1791 |
| Birth place | Virginia, U.S. |
| Death date | September 14, 1863 (aged 71) |
| Death place | Caledonia, Missouri, U.S. |
| Resting place | Methodist Cemetery |
| Party | Democratic |
| Relatives | Lewis F. Linn (brother-in-law) |
| Occupation | Politician, physician |
| Allegiance | United States |
| Battles | Black Hawk War |
James Hugh Relfe (October 17, 1791 – September 14, 1863) was a U.S. Representative from Missouri.
Born in Virginia, Relfe moved to Washington County, Missouri, about 1816 with his father, who settled in Caledonia. He received a limited schooling. He studied medicine and practiced in Caledonia, Missouri. He was appointed a member of the commission to adjust Spanish land claims to fill the vacancy occasioned by the resignation of his brother-in-law, Dr. Lewis F. Linn. He served as member of the State house of representatives 1835-1844. He served in the Black Hawk War. He was appointed United States marshal for the district of Missouri February 17, 1841.
Relfe was elected as a Democrat to the Twenty-eighth and Twenty-ninth Congresses (March 4, 1843 – March 3, 1847). He continued the practice of medicine in Caledonia, Washington County, Missouri, until his death there September 14, 1863. He was interred in the Methodist Cemetery.