Isobe is the name of
- Asaichi Isobe (磯部 浅一, 1905–1937), Lieutenant of the Imperial Japanese Army
- Eriko Isobe (磯辺 絵梨子, born 1977), Japanese volleyball player
- Karin Isobe (礒部 花凜, born 1994), Japanese actress, voice actress, and singer
- Kōichi Isobe (磯部 晃一, born 1958), Lieutenant General of the Japan Ground Self-Defense Force
- Koichi Isobe (礒部 公一, born 1974), Japanese baseball player
- Rua Isobe (磯部 瑠紅, born 2007), Japanese member of the NGT48
- Sata Isobe (磯辺 サタ, 1944–2016), Japanese volleyball player
- Seiji Isobe (磯部 清次, born 1948), Japanese karate instructor
- Tsutomu Isobe (磯部 勉, born 1950), Japanese actor and voice actor
- Yukihisa Isobe (磯辺 行久, born 1935), Japanese artist
Isobe may refer to
- Isobe, Mie, town in the former Shima District, Mie Prefecture, Japan
- 7187 Isobe, main-belt-asteroid named after Syuzo Isobe