| Verifiedfields | verified |
|---|---|
| Watchedfields | verified |
| Verifiedrevid | 449580400 |
| Iupac name | (1R,2S)-2-[Ethyl(methyl)amino]-1-phenyl-1-propanol |
| Width | 180px |
| Tradename | Menetyl; Nethaprin; Novedrin |
| Legal au | S2 |
| Legal br | D1 |
| Legal br comment | [1] |
| Legal status | Withdrawn from market |
| Cas number | 48141-64-6 |
| Atc prefix | None |
| Pubchem | 10734 |
| Unii | 2Y6VQU63E8 |
| Drugbank | DB11587 |
| Chemspiderid | 85308 |
| Chebi | 134847 |
| Chembl | 2110926 |
| Synonyms | Ethylephedrine; N-Ethylephedrine |
| C | 12 |
| H | 19 |
| N | 1 |
| O | 1 |
| Smiles | O[C@H](c1ccccc1)[C@@H](N(CC)C)C |
| Stdinchi | 1S/C12H19NO/c1-4-13(3)10(2)12(14)11-8-6-5-7-9-11/h5-10,12,14H,4H2,1-3H3/t10-,12-/m0/s1 |
| Stdinchikey | IRVLBORJKFZWMI-JQWIXIFHSA-N |
Etafedrine (INN, BAN), sold under the brand name Nethaprin among others and also known as N-ethylephedrine, is a sympathomimetic agent used as a bronchodilator to treat asthma.[2][3][4] It was previously commercially available as both the free base and as the hydrochloride salt from Sanofi-Aventis (now Sanofi) but is now no longer marketed.[citation needed]
Pharmacology
Unlike ephedrine and tyramine, etafedrine does not induce the release of epinephrine or norepinephrine and instead acts as a selective β2-adrenergic receptor agonist, thereby mediating its bronchodilator effects.[4][5]
See also
References
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União. Archived 2023-08-03 at the Wayback Machine. Retrieved 2023-08-15.
- ^ Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 503. ISBN 978-1-4757-2085-3. Retrieved 30 August 2024.
- ^ Morton IK, Hall JM (2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 114. ISBN 978-94-011-4439-1. Retrieved 30 August 2024.
- ^ "Etafedrine: Uses, Interactions, Mechanism of Action". DrugBank Online. 31 December 1983. Retrieved 30 August 2024.
- ^ Lindmar R, Löffelholz K, Stieh-Koch U (1985). "On the mechanism of bronchodilatation by etafedrine". Arzneimittel-Forschung. 35 (3): 602–604. PMID 4039586