| Verifiedrevid | 443584459 |
|---|---|
| Iupac name | (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-3-ylpropan-1-amine |
| Width | 200px |
| Drug name | Dexchlorpheniramine |
| Tradename | Chlor-trimeton, Polaramine |
| Medlineplus | a682543 |
| Legal au | S3 |
| Routes of administration | Oral, Intravenous |
| Elimination half-life | 21 to 27 hours |
| Iuphar ligand | 1210 |
| Cas number | 25523-97-1 |
| Atc prefix | R06 |
| Atc suffix | AB02 |
| Pubchem | 33036 |
| Drugbank | DB13679 |
| Chemspiderid | 30576 |
| Unii | 3Q9Q0B929N |
| Kegg | D07803 |
| Chebi | 4464 |
| Chembl | 1201353 |
| C | 16 |
| H | 19 |
| Cl | 1 |
| N | 2 |
| Smiles | Clc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C |
| Stdinchi | 1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 |
| Stdinchikey | SOYKEARSMXGVTM-HNNXBMFYSA-N |
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.[1][2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.
It came into medical use in 1959 and was patented in 1962.[3]
Pharmacology
Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H1 receptor. A study found that dexchlorpheniramine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.[4]
References
- ^ Theunissen EL, Vermeeren A, Ramaekers JG (January 2006). "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance". British Journal of Clinical Pharmacology. 61 (1): 79–86. doi:10.1111/j.1365-2125.2005.02524.x. PMC 1884990. PMID 16390354
- ^ Ortíz San Román L, Sanavia Morán E, Campos Domínguez M, Peinador García MM (December 2013). "[Anticholinergic syndrome due to dexchlorpheniramine as a cause of urinary retention]". Anales de Pediatria. 79 (6): 400–401. doi:10.1016/j.anpedi.2013.02.014. PMID 23680058
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495.
- ^ Yamamura HI, Snyder SH (May 1974). "Muscarinic cholinergic binding in rat brain". Proceedings of the National Academy of Sciences of the United States of America. 71 (5): 1725–1729. Bibcode:1974PNAS...71.1725Y. doi:10.1073/pnas.71.5.1725. PMC 388311. PMID 4151898