Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.[1][2][3][4]
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.[5] DGL7 is a part of Ran-dependent complex.[6] Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.[7] Expression of DGL7 is found in cancer[8] and stem cells.[9]
References
- ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026
- ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028
- ^ "Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)"
- ^ Bassal S, Nomura N, Venter D, Brand K, McKay MJ, van der Spek PJ (September 2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics. 77 (1–2): 5–7. doi:10.1006/geno.2001.6570. PMID 11543626
- ^ Wilde A (June 2006). ""HURP on" we're off to the kinetochore!". J. Cell Biol.. 173 (6): 829–31. doi:10.1083/jcb.200605150. PMC 2063907. PMID 16785318
- ^ Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW (April 2006). "HURP is part of a Ran-dependent complex involved in spindle formation". Curr. Biol.. 16 (8): 743–54. Bibcode:2006CBio...16..743K. doi:10.1016/j.cub.2006.03.056. PMID 16631581
- ^ Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (July 2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol.. 25 (14): 5789–800. doi:10.1128/MCB.25.14.5789-5800.2005. PMC 1168800. PMID 15987997
- ^ Sanderson HS, Clarke PR (June 2006). "Cell biology: Ran, mitosis and the cancer connection". Curr. Biol.. 16 (12): R466–8. Bibcode:2006CBio...16.R466S. doi:10.1016/j.cub.2006.05.032. PMID 16782004
- ^ Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE (June 2007). "Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene". Stem Cells. 25 (6): 1498–506. doi:10.1634/stemcells.2005-0479. PMID 17322106. S2CID 25347875
Further reading
- Ohara O, Nagase T, Ishikawa K (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res.. 4 (1): 53–9. doi:10.1093/dnares/4.1.53. PMID 9179496
- Bassal S, Nomura N, Venter D (2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics. 77 (1–2): 5–7. doi:10.1006/geno.2001.6570. PMID 11543626
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
- Tsou AP, Yang CW, Huang CY (2003). "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma". Oncogene. 22 (2): 298–307. doi:10.1038/sj.onc.1206129. PMID 12527899. S2CID 24615395
- Mantovani F, Banks L (2004). "Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor". J. Biol. Chem.. 278 (43): 42477–86. doi:10.1074/jbc.M302799200. PMID 12902344
- Laprise P, Viel A, Rivard N (2004). "Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells". J. Biol. Chem.. 279 (11): 10157–66. doi:10.1074/jbc.M309843200. PMID 14699157
- Shu H, Chen S, Bi Q (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942
- Hsu JM, Lee YC, Yu CT, Huang CY (2004). "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region". J. Biol. Chem.. 279 (31): 32592–602. doi:10.1074/jbc.M404950200. PMID 15145941
- Blot V, Delamarre L, Perugi F (2005). "Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes". J. Cell Sci.. 117 (Pt 17): 3983–93. doi:10.1242/jcs.01266. PMID 15286176. S2CID 23757741
- Beausoleil SA, Jedrychowski M, Schwartz D (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A.. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935
- Zhao L, Qin LX, Ye QH (2005). "KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis". J. Cancer Res. Clin. Oncol.. 130 (12): 719–27. doi:10.1007/s00432-004-0595-2. PMC 12161794. PMID 15340842. S2CID 24151704
- Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334
- Yu CT, Hsu JM, Lee YC (2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. Cell. Biol.. 25 (14): 5789–800. doi:10.1128/MCB.25.14.5789-5800.2005. PMC 1168800. PMID 15987997
- Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026
- Nousiainen M, Silljé HH, Sauer G (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A.. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220
- Wong J, Fang G (2006). "HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture". J. Cell Biol.. 173 (6): 879–91. doi:10.1083/jcb.200511132. PMC 2063914. PMID 16769820
- Beausoleil SA, Villén J, Gerber SA (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol.. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292
- Olsen JV, Blagoev B, Gnad F (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983