Crescenzio (kreʃˈʃɛntsjo) is both an Italian form of the male name Crescentius and a surname. It may refer to:
Given name
- Crescenzio Gambarelli (), Italian painter
- Crescenzio Grizi or Crescentius of Jesi (died 1263), Italian Friar Minor
- Crescenzio Nomentano or Crescentius the Younger (died 998), Roman politician and aristocrat
- Crescenzio Onofri (1634–1712/14), Italian painter, draughtsman and engraver
- Crescênzio Rinaldini (1925–2011), Italian-Brazilian Roman Catholic prelate
- Crescenzio Sepe (born 1943), Italian Roman Catholic cardinal
- Crescenzio de Theodora or Crescentius the Elder (died 984), Roman politician and aristocrat
Surname
- Antonello Crescenzio (), Italian painter
- Antonio Crescenzio (), Italian painter
- Giovanni di Crescenzio or John Crescentius (died 1012), Roman politician and aristocrat
- Mario Crescenzio (1942–2024), Italian politician
- Pier Crescenzio or Pietro de' Crescenzi (1230/35–c. 1320), Italian jurist and writer on agriculture