| Verifiedfields | changed |
|---|---|
| Watchedfields | changed |
| Verifiedrevid | 477243444 |
| Iupac name | 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one |
| Width | 200 |
| Legal us | Unscheduled |
| Cas number | 56287-74-2 |
| Atc prefix | none |
| Chembl | 2105918 |
| Pubchem | 2040 |
| Chemspiderid | 1960 |
| Unii | CO4U2C8ORZ |
| Kegg | D01638 |
| C | 16 |
| H | 14 |
| F | 1 |
| N | 3 |
| O | 1 |
| Smiles | O=C1C2=CC(N)=CC=C2N=C(CF)N1C3=CC=CC=C3C |
| Stdinchi | 1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 |
| Stdinchikey | VDOSWXIDETXFET-UHFFFAOYSA-N |
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku.[1] It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor[2] and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.[3]
See also
References
- ^ "2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone". No. 3966731.
- ^ Ochiai T, Ishida R (June 1982). "Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity". Japanese Journal of Pharmacology. 32 (3): 427–38. doi:10.1254/jjp.32.427. PMID 7109348
- ^ Ishikawa T, Kamide R, Niimura M (June 1994). "Photoleukomelanodermatitis (Kobori) induced by afloqualone". The Journal of Dermatology. 21 (6): 430–3. doi:10.1111/j.1346-8138.1994.tb01768.x. PMID 8064007. S2CID 7486566